Impressive, Adrian! You are the scientist among us.
May I, please, ask you a question: how is avocado considered  - good fat or bad
fat?
Thank you for your advice
Eva

"Adrian D. Shaw" wrote:

> Sorry for the late reply, I've been a little busy of late!
>
> On Friday 24 August 2001 14:25, deanp@... wrote:
> >> Adrian D. Shaw wrote:
> >> If you don't get calories you waste away and die!
> >
> >But calorie restriction (with adequate nutrition) is the ONLY
> >intervention shown to extend both the average and maximum lifespan of
> >all species tested to date.
>
> I agree, but you need some calories. What I was pointing out is that calories
> per se aren't bad for you. It is simply the quantity in which you consume
> them which can be bad.
>
> >> >* Saturated fat
> >>
> >> Not bad in itself.
> >
> >Huh?
>
> It depends on the type of saturated fat. Many are bad, for example saturated
> fats from red meat are known to be bad. Other saturated fats are beneficial,
> for example there are studies showing the health benefits of cocoa butter
> (take note chocoholics!)
>
> > The Nurse's health study (1) found:
> >
> > "We estimated that the replacement of 5 percent of energy from
> >saturated fat
> >with energy from unsaturated fats would reduce [cardio vascular
> >disease risk] risk by 42 percent".
>
> Yep, but they don't say what sort of saturated fat. As a broad statement,
> that may be true, but if the subjects were eating only cocoa butter (for
> example) it would not be true.
>
> >Similarly (2) found:
> >
> >"Multivariate linear regression analyses showed that the population
> >intake of saturated fat and the prevalence of smoking were positively
> >associated with population all-cause mortality rates.
>
> Of course it would, because the data used for the X matrix (pre-known values)
> in the multiple linear regression (a poor statistical technique, btw;
> Principal Components Regression is generally a better option) apparently did
> not code for the separate types of saturated fats. Had the X matrix
> differentiated between different types of saturated fatty acids, I am sure
> that correlations would have been found between some (maybe even most)
> saturates and mortality rates, but certainly not all.
>
> (am assuming you are familiar with MLR as you quote it)
>
> I have done quite a bit of research myself in this field; I include below a
> selection of my publications in the area. Yes I accept that many saturated
> fats (particularly, it appears, those of red meat) are not good for your
> health. However, there is strong evidence that soem saturated fats are good.
> There is also some interesting evidence that it maybe the combination of
> fats in our diet that are bad, and that saturated fats alone are not bad,
> given a low or zero polyunsaturated intake. I can't recall for sure, but
> isn't the Inuit diet rather high in saturated fats?
>
> >(1) Hu FB, Stampfer MJ, Manson JE, Rimm E, Colditz GA, Rosner BA,
> >Hennekens
> >CH, Willett WC.
> >Dietary fat intake and the risk of coronary heart disease in women.
> >N Engl J Med. 1997 Nov 20;337(21):1491-9.
> >PMID: 9366580; UI: 98026765
> >
> >(2) Kromhout D, Bloemberg B, Feskens E, Menotti A, Nissinen A.
> >Saturated fat, vitamin C and smoking predict long-term population all-
> >cause
> >mortality rates in the Seven Countries Study.
> >Int J Epidemiol 2000 Apr;29(2):260-5
> >PMID: 10817122
>
> Shaw, A.D. (1997) Multivariate Analysis of Spectroscopic Data from Olive Oil
> using Variable Selection. PhD Thesis, University of Wales
>
> Shaw, A.D., di Camillo, A., Vlahov, G., Jones, A., Bianchi, G., Rowland, J. &
> Kell, D.B. (1997) Discrimination of the Variety and Region of Origin of Extra
> Virgin Olive Oils using 13C NMR and Multivariate Calibration with Variable
> Reduction. Analytica Chimica Acta 348:1-3, 357-374.
>
> Jones, A., Shaw, A.D., Salter, G.J., Bianchi, G. & Kell, D.B. (1998) The
> Exploitation of Chemometric Methods in the Analysis of Spectroscopic Data:
> Application to Olive Oils, in Hamilton, R.J. (Ed), Lipid Analysis in Oils and
> Fats. Blackie Academic & Professional, London, pp. 317-376.
>
> Vlahov, G., Shaw, A.D. & Kell, D.B. (1999) Use of 13C NMR DEPT Pulse Sequence
> and Multivariate Analysis to Discriminate Olive Oil Cultivars. Journal of the
> American Oil Chemists' Society 76:10, 1223-1231
>
> Shaw, A.D., Winson, M.K., Woodward, A.M., McGovern, A., Davey, H.M.,
> Kaderbhai, N., Broadhurst, D.I., Gilbert, R.J., Taylor, J., Timmins, É.M.,
> Alsberg, B.K., Rowland, J.J., Goodacre, R. & Ke ll, D.B. (1999) Rapid
> analysis of high-dimensional bioprocesses using multivariate spectroscopies
> and advanced chemometrics. Adv. Biochem. Eng. 66, 83-113.
>
> Bianchi, G., Giansante, L., Shaw, A. & Kell, D. B. (2001). Chemometric
> criteria for the characterisation of Italian protected denomination of origin
> (DOP) olive oils from their metabolic profiles. Eur. J. Lipid Sci. Technol.
> 103, 141-150.
>
> Regards,
>
> Adrian
>
>
>
>
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